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Thus it would be essentially impossible to design probes that detect SNPs on the short arm of chromosome 21. Less radical repetition occurs in many other . Detection of homozygous SNP changes is often easier than small,. The impossible SNPs can be genotyped after mixing with wild type sample either before or . An empirical comparison of SNPs and microsatellites for parentage and. of such groups in Colony2 was impossible for SNPs because of computation time. we noticed that very few SNPs appeared in multiple publications and decided on. reference database impossible for a single set of ancestry informative SNPs . SNPs (Single Nucleotide Polymorphisms) are called every time a new set.